Ebola

PubMed is more like it: 319 hits for a search for 'ebola', but very few are in journals we have. So what should you DO?

1. read abstracts
2. in PubMed, use the Citation button to look at the MeSH terms (or Descriptors in other databases) and consider reformulating searches using the more precise terminology
3. use the See Related Articles feature
4. choose candidates for ILL very carefully --check date, page length, source, language

One from a journal we do have: Takada et al. A system for functional analysis of Ebola virus glycoprotein. Proc Natl Acad Sci U S A 1997 Dec 23;94(26):14764-14769

A search in Cambridge Scientific Abstracts yields 57 hits for 1992-current, and another 48 for 1982-91. I found several that didn't turn up in PubMed, and I did an advanced search for 'de=ebola virus and pt=review' and was pointed to

TI: Title
    Marburg and ebola viruses
AU: Author
    Feldmann, H; Klenk, H-D
SO: Source
    ADV. VIRUS RES., vol. 47, pp. 1-52, 1996
AB: Abstract
    Filoviruses are among the most pathogenic of human viruses. They
    are classified as "Biological Level 4" agents (WHO; Risk Group 4)
    based on their high mortality rate, person-to-person transmission,
    potential aerosol infectivity, and absence of vaccines and
    chemotherapy. Maximum containment is required for all laboratory
    work with infectious material. Yet, we are only beginning to
    understand the interactions of these viruses with their host, and
    our knowledge on genetics, pathogenicity, and natural history is
    still limited. Even though outbreaks among human and nonhuman
    primates to date have always been self-limited, it is because of
    our ignorance about the natural reservoir, the potential of these
    viruses to be transmitted by aerosol, and the lack of
    immunoprophylactic and chemotherapeutic measures that these
    infections are of great concern to biomedical scientists. Imported
    monkeys and international travel, especially rapid travel within
    the incubation time, are considerable risk factors for
    introduction of filovirus infections into nonendemic countries.
    Limited knowledge of the epidemiology and clinical picture of
    filoviral hemorrhagic fever (HF) and inexperience in diagnosing
    cases and in case management magnify the danger of an
    introduction. Filoviruses, like other RNA viruses, presumably have
    a potential for rapid evolution due to an inherently high error
    rate of the virus-encoded polymerase and a lack of repair
    mechanisms (3). The consequence may be a spectrum of genetic
    variants that are selected by the host for different
    transmissibility, virulence, and other biological properties.
    Changes in socioeconomic structure, such as an increase in human
    population, increase in speed, variety, and frequency of travel,
    and disruption of social structures may augment the development of
    mutant virus populations and the probability of a filovirus
    emerging as a truly serious public health problem (4).
PT: Publication Type
    Journal Article; Review
DE: Descriptors
    Marburg virus; Ebola virus; replication; transmission; travel;
    risk factors; genetic variance